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DIRONA®
Reg. SAGARPA: Q-0021-042
ANALGESIC
VETERINARY USE
INJECTABLE SOLUTION, ANALGESIC, ANTISPASMODIC, ANTIREUMATIC AND ANTIPYRETIC
| FÓRMULA: |
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| Each 100 ml contain |
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1-phenyl-2,3 dimetyl-5-pyrazolone 4 -metylaminometanosulphate sodium (sodic dipyrone)
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50 g |
| Vehicle q.s. |
100 ml |
INDICATIONS:
Election product for administration in all conditions characterized by pain and spasmus of smooth muscles (colic) particularly for pain and spamus control in digestive colic, pains before and during labor.
Pain post-surgery.
An aid in muscular and joint distress therapy in case of arthritis, osteoarthritis, fibrosis, busristis, etc. antireumatic.
Horses: For treating intestinal spamus and painful stimulus of fighting peristalsis.
In stomach acute dilation and to control dizziness and rebel behavior.
Swine: To avoid females to eat their offspring apply 30 ml intramuscular injection.
Dogs: Arthritis pain, arthrosis, post-surgical, traumatic.
| SPECIES |
DOSE |
| CATTLE AND HORSES |
30 – 60 ml |
| COLTS AND CALVES |
10 – 15 ml |
| SWINE |
10 – 30 ml |
| SHEEP AND GOATS |
3 – 8 ml |
| DOGS |
2 – 5 ml |
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These doses are considered average and will be administered and/or repeated according to case severity under veterinary control and supervision.
ROUTE OF ADMINISTRATION: Injectable, intravenous slow or intramuscular deep according to case severity. It must not be administered subcutaneously under any circumstance.
WARNINGS:
- Do not use this product 30 days before slaughter of animals intended for human consumption.
- Do not use for human consumption milk from tretaed animals until 72 hours after last dose.
- Keep in a dark and fresh place for storing.
PRESENTATION: 50 and 100 ml vials
CONSULT VETERINARIAN
MEDICAL PRESCRIPTION IS NECESSARY FOR SALE
Dipyrone
It is a pyrazolone derivate (aminopyrine). It is anti-inflammatory, analgesic and antipyretic, produces relaxation of smooth muscle, particularly in intestinal tract (anti-spasmodic). Inhibits cycloxygenase and cynin responsible of intestinal spasmus. It is excreted mainly in urine, has an elimination half life of 5-6 hours. It is probably than used during long periods of time may cause agranulicytosis and leucopenia.
Since dipyrone is hydrosoluble, it parenteral administration is easy for relief of spasmodic colic. It binds extensively to plasmatic proteins. Elimination speed depends on concentrations, and this is why it is important not to exceed recommended dosing limits.
Dipyrone is used widely for symptomatic relief of pain from lesions in muscle, bones and joints in horses, it effect starts 10 minutes after injectable administration.
It half life in dog is 5 hours and between 80 and 90% is excreted in urine.
Other effect is plaquette aggregation inhibition by a direct effect on endoperoxydase (blocks prostaglandin synthesis) which contributes to its analgesic effect.
It is not recommended for use together with chlorpromazine, because it may induce severe hypothermia. Because of its notable analgesic effect, it is inferred that reaches adequate levels in CNS. May reduce protrombine levels.
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