FERLOCINA®
Reg. SAGARPA: Q-0021-039

ANTIMICROBIAL
VETERINARY USE

INJECTABLE SOLUTION. ANTIMICROBIAL-ANTIINFLAMATORY ACIVITY

FORMULA: 

INDICATIONS:

FERLOCINA® is an excellent wide spectrum antimicrobial association against Gram-positive and Gram-negative bacteria. FERLOCINA® is useful for therapy and prevention of infections  in respiratory and genital and urinary systems produced by germs sensitive to penicillin and streptomycin combined with anti-inflammatory effect of dexametasone.

CATTLE:  Mastitis, pododermatitis, PneumonIa, hemorrhagic septicemia, bacterial complications with diarrhea  and other infections.

HORSES:  Respiratory infections as: pneumonia, bronchitis y pharingitis, hemorrhagic septicemia, equine distemper, diarrhea and onfalophlebitis.

SWINE: Respiratory infections as: pneumonia, hemorrhagic septicemia, exposed and infected wounds.

SHEEP AND GOATS:  Mastitis, respiratory infections as: pneumonia, hemorrhagic septicemia, exposed and infected wounds.

DOSE:

Daily once suspension is prepared.

CATTLE, HORSES.  1 to 2 ml for each 50 kg of body weight. Total content of the vial for an animal from 500 kg of body weight.

SHEEP, SWINE AND GOATS. 1 ml for each 25 kg of body weight.

These doses are considered average and must be repeated every 24 hours, according to the case and kind of infection being treated under supervision of veterinarian.

ROUTE OF ADMINISTRATION:  Deep intramuscular

WARNINGS:

-This product should not be used 21 days before slaughter of animals intended for human consumption.

- Milk or dairy products for human consumption from treated animals shoul not be used, until 7 days from last treatment.

- Keep in a dark and fresh place for storing.

PRESENTATION:          Vials with 5 MU.

CONSULT VETERINARIAN
MEDICAL PRESCRIPTION IS NECESSARY FOR SALE 

Penicillin G procaine hydrolyze in solution, so many times is safer for individuals to administer penicillin that is powder form rather than pre-constituted. Potency of Penicillin G procaine in FERLOCINA® is 900-1050 USP units. It is recommended not to mix with other substances, because it reacts easily, for example with amikacyn, aminofilyn, cephalosporin, fenotyazinics like acepromazine and CDP, oxytetracycline, hydrosoluble vitamins and liposoluble, bycarbonate, calcium solutions, etc.

It has been shown that penicillin G procaine administration without penicillin G benzatine reaches higher concentrations in large animals, which is required for a notable activity of penicillin against more common pathogens sensitive to it. For example, one dose of 9,000 U/kg IM. With a dose like this it is possible to quantify penicillin to levels of 0.1 according to FDA recommendation, plasmatic peak concentration was 0.58 (+/- 0.15) y 0.44 (+/- 0.02) micrograms/ml. At this doses concentrations of 0.1 micrograms/ml are reached for one week. If a higher plasmatic concentration is needed, it is not recommended to elevate dose, but rather reduce dosing interval to 8 or even each 6 hours. In horses a dose of 20,000 UI/kg b.w. is the maximum tolerable (administered at several sites) every 8 hours as short interval and every 12 hours as long interval. It is not recommended to elevate dose, because procaine radical is hardly biotransformed in horses, being 20 times more susceptible to toxicity than humans. In fact it has been reported that most of the “allergies” to penicillin are not that, but a incapacity to transform procaine given a deficiency in blood pseudocolinesterase in horses. In case of a procaine toxicity (tremors, excitation and even prostration with convulsions) use diazepam is recommended.

It is known that the use of FERLOCINA® in neck muscles and not in the leg or another site, helps to get plasmatic penicillin G concentrations at least 50% higher.

Penicillin G procaine is still an excellent option against any streptococcus, many Gram-positive coccus and most of anaerobic including genres Clostridium and Bacillus sp as Bacillus anthracis, Clostridium sp. (not C. Difficile) Fusobacterium and Actinomyces. It is not active against Gram Negative, Rickettsia, mycoplasma y mycrobacteria. Among the diseases that are treated with penicillin are the following: