PAROL T PLUS®
Reg. SAGARPA: Q-0021-085

ANTIPARASITARY
VETERINARY USE

ORAL TABLETS. ORAL ANTIHELMINTIC WIDE SPECTRUM FOR DOGS.

FORMULA:

INDICTIONS: Active against the following parasites: Ascarides, (Toxocara canis, Toxascaris leonina) Trichocephalus, (Trichuris vulgaris) Anchilostomas, (Uncinaria stenocephaia, Ancylostoma caninum, Ancylostoma granulosus).

ADMINISTRATION:

• Put in anterior part of throat and make it swallowed.

• Crush tablet and mix with food.

• Dissolve tablet in small portion of water and mix with food or in drinking water.

• Administer tablet inside a meat ball.

DOSE:

Dogs (puppies): Infestated by ascarides, administer only ½ tablet in the morning. Dogs (adult): Infestated by ascarides, administer 1 tablet in the morning and 1 in the afternoon. Dogs with less than 2 kilograms body weight infestated by several parasites species, administer ½ tablet in the morning and ½ in the afternoon. Dogs with more than 2 kilograms infestated by several parasites species, administer 1 tablet in the morning and 1 tablet in the afternoon. Adult dogs with more than 30 kilograms body weight, administer 2 tablets in the morning and 2 tablets in the afternoon. These doses are considered average and will be used and/or repeated according with case severity under veterinary supervision.

WARNINGS:

• Keep in a dark and fresh place for storing.

PRESENTATION: 100 tablets display ADVERTENCIAS:

CONSULT VETERINARIAN
MEDICAL PRESCRIPTION IS NECESSARY FOR SALE

Mebendazole

Mebendazole differs in its activity mechanism from most of benzimidasole group, because it does not inhibit fumarate reductase enzyme. Instead, it blocks glucose transit to parasite in a very efficient way. It seems that this happens in the parasite’s intestine, where it also blocks tubuline that induces cytoplasmic tubes disorders. This effects blocks transit of several substances, including glucose. This causes glucogen reduction in parasite, which can not synthesize ATP necessary for living and host permanence; parasite elimination is relatively slow with this drug and happens between 24 to 48 hours. In case of taenia (segmented intestine parasites), seems to be secretor granules that are involved in formation and maintenance of external tegumentary tissue, which provide hydrolytic and proteolytic enzymes for extracellular digestion and nutrient absorption. It has been suggested that there is tegument autolysis from taenia for long intracellular storage of lysis enzymes, effect induced by mebendazole.

Absorption:

When drug is administered by the oral route, it is absorbed a little bit more than in monogastric animals. In these, it has a enterohepatic cycle as all benzimidasole. It reaches high concentrations in blood in 2 to 4 days average, and almost never more than 1% of administered dose. It is metabolized only in a small proportion (1% total dose) and a big part is excreted in excrement without change within 24 yo 48 hours. 5 to 10% is excreted in urine and of this portion, only a very small quantity (less than 1%) goes out as decarbolixed metabolite.

Toxicity:

All benzimidasole family have a low toxicity level, but may cause teratogenic effects. It seems that mebendazole is more embryotoxic that its derivates even when reports are only for rats, mice and sheep.

Residues:

Even when absorption is low, drug may be detected until two weeks after administration. Drug is sold in tablet form and is used in sheep, goats, horses, dogs, cats, chicken, birds and monkeys. In some countries it is successfully used in cattle. Mebendazole efficacy is administered by oral route against more common parasites in different species and it varies according to resistance developed by some parasites, in dogs efficacy is almost total.