POXINA FORTE®
Reg. SAGARPA: Q-0021-005

HORMONAL
VETERINARY USE

INJECTABLE SOLUTION. SYNTHETIC OXITOCIC

FORMULA: 

INDICACIONES:

Estimulación de las contracciones uterinas sin provocar espasmos, evita hemorragias posparto, retención placentaria, prolapso uterino, éxtasis de leche, ayuda a la bajada de la leche, coadyuvante en mastitis, acelera el parto normal, ayuda a expulsar la placenta.

INDICATIONS:
Stimulation of uterine contractions without spasms, avoids post-labor hemorrhagic symptoms, placental retention, uterine prolapse, milk stasis, an aid for milk release, an aid in mastitis therapy, accelerates normal labor and helps placental expulsion.

DOSE:
Cattle 2 to 5 ml
Horses 2 to 4 ml
Swine 1 to 4 ml
Sheep and Goats 1 to 5 ml
Dogs and Cats 0.25 to 2 ml

ROUTE OF ADMINISTRATION: Intramuscular, intravenous slow

WARNINGS:
Keep in a dark and fresh place for storing.

PRESENTATION: 10 ml vial

CONSULT VETERINARIAN
MEDICAL PRESCRIPTION IS NECESSARY FOR SALE

Additional Information

Oxytocin is made in magnocellular neurosecretory cells in the supraoptic nucleus and paraventricular nucleus of the hypothalamus and is released into the blood from the posterior lobe of the pituitary gland. Oxytocin is also made by some neurons in the paraventricular nucleus that project to other parts of the brain and to the spinal cord.
Secretion of oxytocin from the neurosecretory nerve endings is regulated by the electrical activity of the oxytocin cells in the hypothalamus. These cells generate action potentials that propagate down axons to the nerve endings in the pituitary; the endings contain large numbers of oxytocin-containing vesicles, which are released by exocytosis when the nerve terminals are depolarised.

The peripheral actions of oxytocin mainly reflect secretion from the pituitary gland. (See oxytocin receptor for more detail on its action.)
• Letdown reflex – in lactating (breastfeeding) mothers, oxytocin acts at the mammary glands, causing milk to be 'let down' into a collecting chamber, from where it can be extracted by sucking at the nipple. Sucking by the infant at the nipple is relayed by spinal nerves to the hypothalamus. The stimulation causes neurons that make oxytocin to fire action potentials in intermittent bursts; these bursts result in the secretion of pulses of oxytocin from the neurosecretory nerve terminals of the pituitary gland.
• Uterine contraction – important for cervical dilation before birth and causes contractions during the second and third stages of labor. Oxytocin release during breastfeeding causes mild but often painful uterine contractions during the first few weeks of lactation. This also serves to assist the uterus in clotting the placental attachment point postpartum. However, in knockout mice lacking the oxytocin receptor, reproductive behavior and parturition is normal.
• Oxytocin and oxytocin receptors are also found in the heart in some rodents, and the hormone may play a role in the embryonal development of the heart by promoting cardiomyocyte differentiation. However, the absence of either oxytocin or its receptor in knockout mice has not been reported to produce cardiac insufficiencies.
• Modulation of hypothalamic-pituitary-adrenal axis activity. Oxytocin, under certain circumstances, indirectly inhibits release of adrenocorticotropic hormone and cortisol and, in those situations, may be considered an antagonist of vasopressin.
Indications:

For induction and aid in labor in animals without dystocia and with cervyx in opening process. Control of hemoragia post labor, by mechanically contracting smooth muscle. An aid in expulsion of retained placenta. For reducing size of prolapsed uterus. An aid in pyomtera therapy.

An aid in mastitis therapy in cattle, sheep and goats as well as MMA syndrome in pigs.